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Sustainable Manufacturing: Green Chemistry Breakthroughs in Pharma
October 17 @ 11:00 am - 12:30 pm PDT
Free
- Sponsored by ACS Webinars & the ACS Green Chemistry Institute
- Oct. 17th, 11:00 am-12:30 pm, Online, Free, Registration required
“Celebrate groundbreaking advancements in green chemistry and engineering in the pharmaceutical industry, featuring the 2024 Peter J. Dunn Award winners. Established in 2016, the Award recognizes exceptional industrial implementations that achieve significant environmental, safety, cost, and efficiency improvements over existing technologies. This year’s honorees, GSK and Boehringer Ingelheim, have set new standards in sustainable manufacturing.
GSK’s team developed a second-generation route for manufacturing the cancer drug maleimidocaproyl monomethyl auristatin F (mcMMAF) which reduces solvent consumption by 16,160 kg per kilogram of product, cuts greenhouse gas emissions by 71 percent, and slashes energy consumption by 76 percent. Join Danny Mancheno, a Research Scientist at GSK as he discusses their innovative approach that also eliminated single-use silica gel chromatographic separations, achieving an impressive 76 percent reduction in Process Mass Intensity (PMI). Boehringer Ingelheim’s team created a highly efficient 3-step synthesis for Spiroketone CD 7659, used across multiple projects. Join Yongda Zhang, a Distinguished Research Fellow in Process Research at Boehringer Ingelheim as he discusses how their process improved yield nearly five-fold, reduced solvent usage by 99 percent, and eliminated halogenated solvents. The sustainability impact was significant, with a PMI of 117, an outstanding Relative Process Greenness (RPG) score of 72 percent, and a top-tier innovation Green Aspiration Level (iGAL). Scalable to meet increasing demand, learn how their method will save over 69 million kg of waste at one of the world’s largest pharmaceutical companies.
Don’t miss this opportunity to learn from industry leaders in the sustainability space as they share insights into these award-winning projects and their contributions to a greener future. This ACS Webinar is moderated by John Tucker of Neurocrine Biosciences and is co-produced by the ACS Green Chemistry Institute Pharmaceutical Roundtable.”
What You Will Learn
- The process development of a more sustainable 2nd generation route to peptide- maleimidocaproyl monomethyl auristatin F (MMAF)-the cytotoxic payload for Blenrep®
- How, in spite of safety, regulatory, COVID challenges as well as a short timeline, the Blenrep team at GSK developed a more sustainable process for a complex anti-body drug conjugate payload
- What was the sustainability improvement for this novel antibody drug conjugate (ADC) for the treatment of multiple myeloma
- What is green asymmetric allylic alkylation
- What is a telescoping process, what are some current applications, and what design considerations should be made
- How to achieve a reduction of waste and cost through Eco-design