“The United States has a key position in the global science and engineering (S&E) enterprise. As S&E capacity has increased globally, the U.S. position has changed despite increases in the absolute amount of S&E activity in the United States. Although the United States was key in the rapid development of COVID-19 vaccines, the data in this report show the U.S. S&E enterprise could be strengthened. The data reveal capacity-building areas in the U.S. S&E enterprise in the STEM education system and STEM workforce, R&D investment, and innovation activities.” (publisher’s description)